Ruiz Cáceres, InmaculadaHermida Romero, TeresaGuerra Merino, IsabelPortu Zapirain, JosebaPérez Mies, BelénSánchez Conde, MatildeAlonso Riaño, MarinaRubio Campillo, RafaelFortés Alen, JoseVidal González, ÁnxelaSalas Antón, ClaraMúñez, ElenaSánchez Sánchez, RafaelCorona Mata, DianaAldecoa Ansorregui, IbanMiró Meda, José M. (José María), 1956-Beloqui Pérez de Obanos, RaquelIbero, CarlosGómez Román, JavierFariñas, María CarmenTabuyo Bello, TeresaAlava, Enrique deCisneros, José MiguelMatias-Guiu, Xavier, 1958-Rivero, AntonioNecroCOVID Study Group2023-12-112023-12-112023-07-042296-858Xhttps://hdl.handle.net/2445/204400IntroductionWhole-body autopsies may be crucial to understand coronavirus disease 2019 (COVID-19) pathophysiology. We aimed to analyze pathological findings in a large series of full-body autopsies, with a special focus on superinfections. MethodsThis was a prospective multicenter study that included 70 COVID-19 autopsies performed between April 2020 and February 2021. Epidemiological, clinical and pathological information was collected using a standardized case report form. ResultsMedian (IQR) age was 70 (range 63.75-74.25) years and 76% of cases were males. Most patients (90%,) had at least one comorbidity prior to COVID-19 diagnosis, with vascular risk factors being the most frequent. Infectious complications were developed by 65.71% of the patients during their follow-up. Mechanical ventilation was required in most patients (75.71%) and was mainly invasive. In multivariate analyses, length of hospital stay and invasive mechanical ventilation were significantly associated with infections (p = 0.036 and p = 0.013, respectively). Necropsy findings revealed diffuse alveolar damage in the lungs, left ventricular hypertrophy in the heart, liver steatosis and pre-infection arteriosclerosis in the heart and kidneys. ConclusionOur study confirms the main necropsy histopathological findings attributed to COVID-19 in a large patient series, while underlining the importance of both comorbid conditions and superinfections in the pathology.11 p.application/pdfengcc by (c) Ruiz Cáceres, Inmaculada et al., 2023http://creativecommons.org/licenses/by/3.0/es/COVID-19Fisiologia patològicaCOVID-19Pathological physiologyinfo:eu-repo/semantics/article2023-08-17info:eu-repo/semantics/openAccess37484846