Sagastagoitia Fornie, MartaMorán Fernández, LauraBlázquez Bermejo, ZorbaDíaz Molina, BeatrizGómez Bueno, ManuelAlmenar Bonet, LuisLópez Granados, AmadorGonzález Vílchez, FranciscoMirabet Pérez, SoniaGarcía Romero, ElenaSobrino Márquez, Jose M.Rábago Juan Aracil, GregorioCastel Lavilla, Maria ÀngelsBlasco Peiró, TeresaGarrido Bravo, IrisFuente Galán, Luis de laMuñiz, JavierCrespo Leiro, María G.2023-07-252023-07-252023-05-191432-2277https://hdl.handle.net/2445/201167In this observational and multicenter study, that included all patients who underwent a heart transplantation (HT) in Spain from 1984 to 2018, we analyzed the incidence, management, and prognosis of colorectal cancer (CRC) after HT. Of 6,244 patients with a HT and a median follow-up of 8.8 years since the procedure, 116 CRC cases (11.5% of noncutaneous solid cancers other than lymphoma registered) were diagnosed, mainly adenocarcinomas, after a mean of 9.3 years post-HT. The incidence of CRC increased with age at HT from 56.6 per 100,000 person-years among under 45 year olds to 436.4 per 100,000 person-years among over 64 year olds. The incidence rates for age-at-diagnosis groups were significantly greater than those estimated for the general Spanish population. Curative surgery, performed for 62 of 74 operable tumors, increased the probability of patient survival since a diagnosis of CRC, from 31.6% to 75.7% at 2 years, and from 15.8% to 48.6% at 5 years, compared to patients with inoperable tumors. Our results suggest that the incidence of CRC among HT patients is greater than in the general population, increasing with age at HT.8 p.application/pdfengcc by (c) Sagastagoitia Fornie, Marta et al, 2023http://creativecommons.org/licenses/by/3.0/es/Càncer colorectalTrasplantament cardíacColorectal cancerHeart transplantationinfo:eu-repo/semantics/article2023-07-17info:eu-repo/semantics/openAccess37275465