Vicent Gil, MurielRaventós, BeatrizMarín Martínez, Eduardo D.González Simarro, SaraMartínez-Arán, Anabel, 1971-Bonnín Roig, Caterina del MarTrujols, JoanPérez Blanco, Josefinade Diego Adeliño, JavierPuigdemont, DolorsSerra Blasco, MaríaCardoner, N. (Narcís)Portella Moll, María Jesús2021-05-062021-05-062019-05-061471-244Xhttps://hdl.handle.net/2445/177070Background: Given the limitation of pharmacological treatments to treat cognitive symptoms in patients with Major Depressive Disorder (MDD), cognitive remediation programs has been proposed as a possible procognitive intervention but findings are not conclusive. This study investigates the efficacy of an INtegral Cognitive REMediation (INCREM) that includes a combination of a Functional Remediation (FR) strategy plus a Computerized Cognitive Training (CCT) in order to improve not only cognitive performance but also the psychosocial functioning and the quality of life. Methods: A single blind randomized controlled clinical trial in 81 patients with a diagnosis of MDD in clinical remission or in partial remission. Participants will be randomized to one of three conditions: INCREM (FR + CCT), Psychoeducation plus online games and Treatment As Usual (TAU). Intervention will consist in 12 group sessions, of approximately 110 min once a week. The primary outcome measure will be % of change in psychosocial functioning after treatment measured by the Functional Assessment Short Test (FAST); additionally, number of sick leaves and daily activities will also be recorded as pragmatic outcomes. Discussion: To our knowledge, this is the first randomized controlled clinical trial using a combination of two different approaches (FR + CCT) to treat the present cognitive deficits and to promote their improvements into a better psychosocial functioning. Trial registration: Clinical Trials NCT03624621 . Date registered 10th of August 2018 and last updated 24th August 2018.8 p.application/pdfengcc-by (c) Vicent Gil, Muriel et al., 2019http://creativecommons.org/licenses/by/3.0/esDepressió psíquicaRehabilitació cognitivaMental depressionCognitive remediationinfo:eu-repo/semantics/article6926482021-05-06info:eu-repo/semantics/openAccess31060604