Hernández Rojas, ZojainaDalmau Llorca, Maria RosaAguilar Martín, CarinaGonçalves, Alessandra QueirogaCasajuana, MarcFernández Sáez, JoséRodríguez Cumplido, DoloresForcadell Drago, EmmaCarrasco Querol, NoèliaPepió i Vilaubí, Josep M.Alegret, Josep M.2021-03-032021-03-032020-09-04https://hdl.handle.net/2445/174574Background: Anticoagulant therapy is used for stroke prevention and proved to be effective and safe in the long term. The study aims to analyse the cost-effectiveness relationship of using of direct-acting oral anticoagulants vs vitamin K antagonists to prevent ischaemic stroke in patients with nonvalvular atrial fibrillation, including all the active ingredients marketed in Spain, prescribed for 2 years in the Primary Care service of the Institut Català de la Salut. Methods: Population-based cohort study, in which the cost of the 2 treatment groups will be evaluated. Direct costs (pharmacy, primary care, emergency and hospitalization) and indirect costs (lost productivity) will be included from a social perspective. Effectiveness (assessed as the occurrence of a health event, the 1 of primary interest being stroke) will be determined, with a 2-year time horizon and a 3% discount rate. The average cost of the 2 groups of drugs will be compared using a regression model to determine the factors with the greatest influence on determining costs. We will carry out a univariate ('one-way') deterministic sensitivity analysis. Discussion: We hope to provide relevant information about direct and indirect costs of oral anticoagulants, which, together with aspects of effectiveness and safety, could help shape the consensual decision-making of evaluating bodies.7 p.application/pdfengcc by (c) Hernández Rojas, Zojaina et al., 2020http://creativecommons.org/licenses/by/3.0/es/Cost de l'assistència sanitàriaCatalunyaAssaigs clínicsAnticoagulants (Medicina)Vitamines KCost of medical careCataloniaClinical trialsAnticoagulants (Medicine)Vitamin Kinfo:eu-repo/semantics/article2021-03-02info:eu-repo/semantics/openAccess32899067