Álvarez Zaballos, SaraGonzález-Ramallo, VíctorQuintana, EduardMuñoz, PatriciaDe la Villa, SofíaFariñas, Maria CarmenArnáiz de las Revillas, FranciscoAlarcón, Aristides deRodríguez-Esteban, M. ÁngelesMiró Meda, José M. (José María), 1956-Goenaga Sánchez, Miguel ÁngelGoikoetxea Agirre, Ane JosuneGarcía Vázquez, ElisaBoix Palop, LucíaMartínez-Sellés, ManueGrupo de Apoyo al Manejo de la Endocarditis infecc2023-09-212023-09-212022-08-132077-0383https://hdl.handle.net/2445/202163Background. Infective endocarditis (IE) is a severe condition. Our aim was to describe the profile and prognosis of patients with multivalvular infective endocarditis (MIE) and compare them to single-valve IE (SIE). Methods. We used a retrospective analysis of the Spanish IE Registry (2008−2020). Results. From 4064 definite cases of valvular IE, 577 (14.2%) had MIE. In patients with MIE, the most common locations were mitral (552, 95.7%) and aortic (550, 95.3%), with mitral-aortic involvement present in 507 patients (87.9%). The most common etiologies were S. viridans (192, 33.3%) and S. aureus (113, 19.6%). MIE involved only native valves in 450 patients (78.0%). Compared with patients with SIE, patients with MIE had a similar age (69 vs. 67 years, respectively, p = 0.27) and similar baseline characteristics, but were more frequently men (67.1% vs. 72.9%, p = 0.005) and had a higher incidence of intracardiac complications (36.2% vs. 50.4%, p < 0.001), heart failure (42.7% vs. 52.9%, p < 0.001), surgical indication (67.7 vs. 85.1%, p < 0.001), surgery (46.3% vs. 56.3%), and in-hospital mortality (26.9% vs. 34.3%, p < 0.001). MIE was an independent predictor of in-hospital mortality (odds ratio (OR) 1.3, 95% confidence interval (CI) 1.1−1.7, p = 0.004) but did not have an independent association with 1-year mortality (OR 1.1, 95% CI 0.9−1.4, p = 0.43). Conclusions. About one-seventh of the valvular IE patients had MIE, mainly due to mitral-aortic involvement. MIE is associated with a poor in-hospital prognosis. An early diagnosis and treatment of IE might avoid its spread to a second valve.10 p.application/pdfengcc-by (c) Álvarez Zaballos, Sara et al., 2022https://creativecommons.org/licenses/by/4.0/EndocarditisPronòstic mèdicVàlvules cardíaquesMortalitatEndocarditisPrognosisHeart valvesMortalityinfo:eu-repo/semantics/article7296342023-09-21info:eu-repo/semantics/openAccess932916336012974