Santos García, DiegoLaguna, AriadnaHernández Vara, JorgeDeus Fonticoba, Teresa deCores Bartolomé, CarlosFeal Painceiras, Maria J.Íñiguez Alvarado, Maria CristinaGarcía Díaz, IagoJesús, SilviaBoungiorno, Maria TeresaPlanellas, LluísCosgaya, MarinaGarcía Caldentey, JuanCaballol, NúriaLegarda, InesCabo, IriaLópez Manzanares, LydiaGonzález Aramburu, IsabelÁvila Rivera, Maria A.Gómez Mayordomo, VíctorNogueira, VíctorPuente, VíctorDotor García-Soto, JulioBorrué, CarmenSolano Vila, BertaÁlvarez Sauco, MaríaVela, LydiaEscalante, SoniaCubo, EstherCarrillo Padilla, FranciscoCastrillo, Juan C. MartínezSánchez Alonso, PilarAlonso Losada, Maria G.López Ariztegui, NuriaGastón, ItziarKulisevsky, JaimeMenéndez González, ManuelSeijo, ManuelRúiz Martínez, JavierValero, CaridadKurtis, MónicaGonzález Ardura, JessicaAlonso Redondo, RubenOrdás, CarlosLópez Díaz, Luis M.Mcafee, DarrianMartinez Martin, PabloMir, PabloCOPPADIS Study Group2023-05-082023-05-082023-02-072077-0383https://hdl.handle.net/2445/197671Background and objective: Sex plays a role in Parkinson's disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross-sectional and a two-year follow-up analysis were conducted. Univariate analyses and general linear model repeated measure were used. Results: At baseline, data from 681 PD patients (mean age 62.54 +/- 8.93) fit the criteria for analysis. Of them, 410 (60.2%) were males and 271 (39.8%) females. There were no differences between the groups in mean age (62.36 +/- 8.73 vs. 62.8 +/- 9.24; p = 0.297) or in the time from symptoms onset (5.66 +/- 4.65 vs. 5.21 +/- 4.11; p = 0.259). Symptoms such as depression (p < 0.0001), fatigue (p < 0.0001), and pain (p < 0.00001) were more frequent and/or severe in females, whereas other symptoms such as hypomimia (p < 0.0001), speech problems (p < 0.0001), rigidity (p < 0.0001), and hypersexuality (p < 0.0001) were more noted in males. Women received a lower levodopa equivalent daily dose (p = 0.002). Perception of quality of life was generally worse in females (PDQ-39, p = 0.002; EUROHIS-QOL8, p = 0.009). After the two-year follow-up, the NMS burden (Non-Motor Symptoms Scale total score) increased more significantly in males (p = 0.012) but the functional capacity (Schwab and England Activities of Daily Living Scale) was more impaired in females (p = 0.001). Conclusion: The present study demonstrates that there are important sex differences in PD. Long-term prospective comparative studies are needed.16 p.application/pdfengcc by (c) Santos García, Diego et al, 2023http://creativecommons.org/licenses/by/3.0/es/Malaltia de ParkinsonFactors sexuals en les malaltiesParkinson's diseaseSex factors in diseaseinfo:eu-repo/semantics/article2023-04-17info:eu-repo/semantics/openAccess36835866