Jonge, Peter deRoest, Annelieke M.Lim, Carmen C. W.Florescu, Silvia E.Bromet, Evelyn J.Stein, Dan J., 1962-Harris, Meredith G.Nakov, VladimirCaldas de Almeida, José MiguelLevinson, DaphnaAl-Hamzawi, Ali ObaidHaro Abad, Josep MariaViana, Maria CarmenBorgs, GuiO'Neill, SiobhanGirolamo, Giovanni deDemyttenaere, KoenGureje, OyeIwata, NoboruLee, SingHu, ChiyiKaram, AimeeMoskalewicz, JacekKovess-Masfety, VivianeNavarro Mateu, FernandoOakley Browne, MarkPiazza, MariaPosada Villa, JoséTorres, YolandaHave, Margreet tenKessler, Ronald C.Scott, Kate M. (Kate Margaret), 1960-2019-02-112019-02-112016-12-011091-4269https://hdl.handle.net/2445/128129CONTEXT: The scarcity of cross-national reports and the changes in Diagnostic and Statistical Manual version 5 (DSM-5) regarding panic disorder (PD) and panic attacks (PAs) call for new epidemiological data on PD and PAs and its subtypes in the general population. OBJECTIVE: To present representative data about the cross-national epidemiology of PD and PAs in accordance with DSM-5 definitions. DESIGN AND SETTING: Nationally representative cross-sectional surveys using the World Health Organization Composite International Diagnostic Interview version 3.0. PARTICIPANTS: Respondents (n = 142,949) from 25 high, middle, and lower-middle income countries across the world aged 18 years or older. MAIN OUTCOME MEASURES: PD and presence of single and recurrent PAs. RESULTS: Lifetime prevalence of PAs was 13.2% (SE 0.1%). Among persons that ever had a PA, the majority had recurrent PAs (66.5%; SE 0.5%), while only 12.8% fulfilled DSM-5 criteria for PD. Recurrent PAs were associated with a subsequent onset of a variety of mental disorders (OR 2.0; 95% CI 1.8-2.2) and their course (OR 1.3; 95% CI 1.2-2.4) whereas single PAs were not (OR 1.1; 95% CI 0.9-1.3 and OR 0.7; 95% CI 0.6-0.8). Cross-national lifetime prevalence estimates were 1.7% (SE 0.0%) for PD with a median age of onset of 32 (IQR 20-47). Some 80.4% of persons with lifetime PD had a lifetime comorbid mental disorder. CONCLUSIONS: We extended previous epidemiological data to a cross-national context. The presence of recurrent PAs in particular is associated with subsequent onset and course of mental disorders beyond agoraphobia and PD, and might serve as a generic risk marker for psychopathology.23 p.application/pdfeng(c) Wiley, 2016Atacs de pànicTrastorns de pànicEpidemiologiaPanic attacksPanic disordersEpidemiologyinfo:eu-repo/semantics/article6679172019-02-11info:eu-repo/semantics/openAccess27775828