Riba, JordiRodríguez Fornells, AntoniMorte, AdelaidaMünte, Thomas F.Barbanoj, Manel J.2015-04-282015-04-2820050270-6474https://hdl.handle.net/2445/65265Noradrenergic neurotransmission has been associated with the modulation of higher cognitive functions mediated by the prefrontal cortex. In the present study, the impact of noradrenergic stimulation on the human action-monitoring system, as indexed by eventrelated brain potentials, was examined. After the administration of a placebo or the selective 2 -adrenoceptor antagonist yohimbine, which stimulates firing in the locus ceruleus and noradrenaline release, electroencephalograpic recordings were obtained from healthy volunteers performing a letter flanker task. Yohimbine led to an increase in the amplitude of the error-related negativity in conjunction with a significant reduction of action errors. Reaction times were unchanged, and the drug did not modify the N2 in congruent versus incongruent trials, a measure of preresponse conflict, or posterror adjustments as measured by posterror slowing of reaction time. The present findings suggest that the locus ceruleus<br>noradrenaline system exerts a rather specific effect on human action monitoring.5 p.application/pdfengcc-by-nc-sa (c) Riba, J. et al., 2005http://creativecommons.org/licenses/by-nc-sa/3.0/esPotencials evocats (Electrofisiologia)Escorça cerebralCatecolaminesConducta (Psicologia)Evoked potentials (Electrophysiology)Cerebral cortexCatecholaminesHuman behaviorinfo:eu-repo/semantics/article5221392015-04-28info:eu-repo/semantics/openAccess15858063