Amat Tusón, MercedesGhirardi, ElenaNavío, LauraGriera Farres, RosaLlor Brunés, NúriaMolins i Grau, EliesBosch Cartes, Joan2016-06-062016-06-062013-11-180947-6539https://hdl.handle.net/2445/99269Up to four stereocenters with a well-defined configuration are generated in a single synthetic step by the cyclocondensation of (R)-phenylglycinol or (1S,2R)-1-amino-2-indanol with stereoisomeric mixtures (racemates, meso forms, diastereoisomers) of cyclohexanone-based δ-keto-acid and δ-keto-diacid derivatives in enantio- and diastereoconvergent processes that involve dynamic kinetic resolution and/or desymmetrization of enantiotopic groups. A detailed analysis of the stereochemical outcome of this process is presented. This method provides easy access to enantiopure 8- and 6,8-substituted cis-decahydroquinolines, including alkaloids of the myrioxazine family.6 p.application/pdfeng(c) Wiley-VCH, 2013Química orgànicaAlcaloidesSíntesi asimètricaLactamesCompostos heterocíclicsOrganic chemistryAlkaloidsAsymmetric synthesisLactamsHeterocyclic compoundsinfo:eu-repo/semantics/article6287982016-06-06info:eu-repo/semantics/openAccess24115323