Matía-Martín, PilarShyam, SangeethaGarcía Gavilán, JesúsPaz-Graniel, IndiraGaforio, José J.Martínez-González, Miguel Ángel, 1957-Corella Piquer, DoloresMartínez Hernández, José AlfredoAlonso Gómez, Ángel M.Wärnberg, JuliaVioque, JesúsRomaguera, DoraLópez-Miranda, JoséEstruch Riba, RamonTinahones, Francisco JoséLapetra, JoséSerra-Majem, J. LuisBueno-Cavanillas, AuroraTur, Josep AntoniMartín-Sánchez, V.Pintó Sala, XavierVidal i Cortada, JosepVázquez, ClotildeDaimiel, LidiaRos Rahola, EmilioFernández Aranda, FernandoNishi, Stephanie KGarcia-Regata, OscarToledo, EstefaníaAsensio, Eva MCastañer Niño, OlgaGarcia-Rios, AntonioTorres-Collado, LauraGómez Gracia, EnriqueZulet, M. AngelesGoñi Ruiz, NuriaCasas Rodríguez, Rosa M.Cano Ibáñez, NaomiTojal-Sierra, LucasGómez-Perez, AMSorlí, José VCinza-Sanjurjo, SergioMartín-Peláez, SandraPeña-Orihuela, Patricia JOncina-Canovas, AlejandroPerez-Araluce, RafaelZomeño, Maria DoloresChaplin, AliceDelgado Rodriguez, MiguelBabio, NancyFitó Colomer, MontserratSalas-Salvadó, Jordi2025-12-172025-12-172023-10-131741-7015https://hdl.handle.net/2445/225021Background: Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk. Methods: This analysis included 6874 men and women (aged 55-75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5-6 years before the pandemic and their changes at the visit prior to censoring. Results: At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk. Conclusions: In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19.13 p.application/pdfengcc-by (c) Shyam S et al., 2023http://creativecommons.org/licenses/by/4.0/ObesitatVellesaCOVID-19ObesityOld ageCOVID-19info:eu-repo/semantics/article7411582025-12-17info:eu-repo/semantics/openAccess37833678