Zhang, QianPizzorno, AndrésMiorin, LisaBastard, PaulGervais, AdrianLe Voyer, TomBizien, LucyManry, JeremyRosain, JérémiePhilippot, QuentinGoavec, KelianCondino-neto, AntonioDominguez Pinilla, NereaMeyts, IsabelleAydillo, TeresaOkamoto, KeisukeAnderson, Mark S.Soumaré, AïchaWroblewski, IsabelleKaramitros, TimokratisRuiz Hernandez, José JuanCovid Human Genetic EffortMedina, Rafael A.Kisand, KaiRamírez Duque, NievesFeys, SimonRomero Oraa, LauraKuo, Chen-yenLei, Wei-teResnick, IgorQuintana Murci, LluisMilner, Joshua D.Rombauts, AlexanderJeanne, MichelGarcía Salum, TamaraKu, Cheng-lungVan De Beek, DiederikHsieh, Elena W.Y.Tal, GalitFournet, ThomasCerba Healthcare GroupPatural, HuguesPesole, GrazianoZatz, MayanaNovelli, GiuseppeMorio, TomohiroLyon Antigrippe Working GroupArias, Andrés A.Shahrooei, MohammedRovina, NikolettaRodríguez-Gallego, CarlosPuel, AnneJouanguy, EmmanuelleVinh, Donald C.Uddin, K.m. FurkanAbel, LaurentSu, Helen C.Bonneaudeau, BrigitteHenny, JosephMogensen, Trine H.Cobat, AurélieCasari, GiorgioSlaby, OndrejRamaswamy, SathishkumarAbelenda Alonso, GabrielaKisand, KaiMorel, PascalFragkou, Paraskevi C.Argaud, LaurentCannet, DorothéeVanderbeke, LoreBelot, AlexandreShcherbina, AnnaAl-muhsen, SalehBiggs, Catherine M.Bogunovic, DusanGallian, PierreHusebye, EysteinPlanas, Anna M.Heath, James R.Von Bernuth, HorstKu, Cheng-lungDufouil, CaroleHagin, DavidBolze, AlexandreEtablissement Français Du Sang Study GroupFroidure, AntoineFievet, NathalieLaurent, EmilieGalani, Ioanna EvdokiaPothier, PierreGregersen, Peter K.Lemonnier, SylviePadey, BlandineCarratalà, JordiSpaan, András N.Darmon, MichaelGrimbacher, BodoPalomo, VirginiaDel Mar Muñoz Garcia, MariaZawadzki, PawelHenrickson, Sarah E.Haerynck, FilomeenO'farrelly, ClionaMorand, PatriceNiubó, JordiRosa Calatrava, ManuelTrouillet Assant, SophieLachaize, MorganeJarvis, Erich D.Okada, SatoshiVanker, MarttiBryceson, YenanLing, YunCooper, Megan A.Lucas, Carrie L.Maniatis, TomGallardo Ríos, RafaelaRomero Vázquez, Gloria MaríaNavarrete, NicolásRichard, PascaleDesai, MurkeshMansouri, DavoodCastagnoli, RiccardoZins, MarieMaródi, LászlóMironska, KristinaRapti, VasilikiBaris Feldman, HagitLau, Yu-lungPozzetto, BrunoBoeuf, BenoitRenia, LaurentTancevski, IvanFerres, MarcelaFranco, José LuisImai, KohsukeOzcelik, TayfunPan-Hammarström, QiangAl-mulla, FahdPape, Jean W.Triantafyllia, VasilikiRodríguez de Castro, FelipeEtzioni, AmosSouweine, BertrandPérez de Diego, RebecaWauters, JoostSánchez Céspedes, JavierSánchez Cordero, Maria JoseUddin, Mohammed J.Solé Violán, JordiPerroquin, MagaliNg, Lisa F.P.Ferreres, JoséBriones, MarisaAbou Tayoun, AhmadLe Corre, NicoleSnow, Andrew L.Temel, Şehime GülsünTsiodras, SotiriosTzourio, ChristopheMerino Díaz, LauraCoeuret Pellicer, MireilleNotarangelo, Luigi D.Flaig, AmandineJavouhey, EtienneSaker, KahinaTurvey, Stuart E.Pujol, Aurora, 1968-Cognasse, FabriceSancho Shimizu, VanessaTiberghien, PierreReipi Inf Working GroupNadif, RachelHanna, SuhairRodríguez Gallego, CarlosFlores, CarlosSeppänen, Mikko R.J.Constances CohortGoldberg, MarcelBrodin, PetterAndreakos, EvangelosLe Got, StéphaneOzguler, AnnaQuenot, Jean PierreGarcía Sastre, AdolfoChristodoulou, JohnNovelli, AntonioPerlin, David S.Cordero, ElisaColomb, BenoitSärekannu, KaritaCupic, AnastasijaMehlal Sedkaoui, SouadSallette, JérômeHernu, RomainBustamante, Carlos D.Bondarenko, AnastasiiaLina, BrunoConstantinescu, Stefan N.Drolet, Beth A.Halwani, RabihCasalegno, Jean SebastienSchwebel, CaroleSalamanca Rivera, CeliaAiuti, Alessandro3C-Dijon StudyTangye, Stuart G.Martin, FernandoDalgard, Clifton L.Retamar Gentil, PilarDebette, StéphanieEspinosa Padilla, SaraHamzeh Cognasse, HindBelot, AlexandreAbel, LaurentSoler Palacín, PereAbad Arranz, MariaAguilar Guisado, ManuelaFellay, JacquesMeyts, IsabelleCasanova, Jean-LaurentGonzález Granado, Luis IgnacioButte, Manish J.Wauters, JoostItan, YuvalHaerynck, FilomeenEscoresca Ortega, AnaPeigue Lafeuille, HeleneValiente, AdoraciónKoltsida, OuraniaEl Baghdadi, JamilaTiberghien, PierreBalsera-manzanero, MaríaZins, MarieHammarström, LennartQueromes, GregoryBousfiha, Ahmed A.Andreakos, EvangelosNotarangelo, Luigi D.Debette, StéphanieSediva, AnnaPrando, Carolina2022-12-232022-12-232022-09-161540-9538https://hdl.handle.net/2445/191806In an international cohort of 279 patients with hypoxemic influenza pneumonia, we identified 13 patients (4.6%) with autoantibodies neutralizing IFN-alpha and/or -omega, which were previously reported to underlie 15% cases of life-threatening COVID-19 pneumonia and one third of severe adverse reactions to live-attenuated yellow fever vaccine. Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies neutralizing IFN-alpha 2 alone (five patients) or with IFN-omega (eight patients) from a cohort of 279 patients (4.7%) aged 6-73 yr with critical influenza pneumonia. Nine and four patients had antibodies neutralizing high and low concentrations, respectively, of IFN-alpha 2, and six and two patients had antibodies neutralizing high and low concentrations, respectively, of IFN-omega. The patients' autoantibodies increased influenza A virus replication in both A549 cells and reconstituted human airway epithelia. The prevalence of these antibodies was significantly higher than that in the general population for patients <70 yr of age (5.7 vs. 1.1%, P = 2.2 x 10(-5)), but not >70 yr of age (3.1 vs. 4.4%, P = 0.68). The risk of critical influenza was highest in patients with antibodies neutralizing high concentrations of both IFN-alpha 2 and IFN-omega (OR = 11.7, P = 1.3 x 10(-5)), especially those <70 yr old (OR = 139.9, P = 3.1 x 10(-10)). We also identified 10 patients in additional influenza patient cohorts. Autoantibodies neutralizing type I IFNs account for similar to 5% of cases of life-threatening influenza pneumonia in patients <70 yr old.29 p.application/pdfengcc by (c) Zhang, Qian et al., 2022http://creativecommons.org/licenses/by/3.0/es/GripPneumòniaAutoanticossosInfluenzaPneumoniaAutoantibodiesinfo:eu-repo/semantics/article2022-12-20info:eu-repo/semantics/openAccess36112363