Rodríguez Urgellés, EnedCasas Torremocha, DianaSancho Balsells, AnnaBallasch, IvanGarcía-García, EstherMiquel Rio, LluísManasanch, ArnauDel Castillo, IgnacioChen, WanqiPupak, AnikaBrito, VerónicaTornero, DanielRodríguez Allué, Manuel JoséBortolozzi Biasoni, AnalíaSánchez-Vives, María VictoriaGiralt Torroella, AlbertAlberch i Vié, Jordi, 1959-2024-02-152023-11-211420-682Xhttps://hdl.handle.net/2445/207639Here, we demonstrate in a HD mouse model a clear and early thalamo-striatal aberrant connectivity associated with a reduction of thalamic Foxp2 levels. Recovering thalamic Foxp2 levels in the mouse rescued motor coordination and sensory skills concomitant with an amelioration of neuropathological features and with a repair of the structural and functional connectivity through a restoration of neurotransmitter release. In addition, reduction of thalamic Foxp2 levels in wild type mice induced HD-like phenotypes.25 p.application/pdfengcc by (c) Rodríguez Urgellés, Ened et al., 2023http://creativecommons.org/licenses/by/3.0/es/Corea de HuntingtonHipotàlemGanglis basalsNeurones sensorialsElectrofisiologiaHuntington's choreaHypothalamusBasal gangliaSensory neuronsElectrophysiologyinfo:eu-repo/semantics/article10.1007/s00018-023-05015-z7418992024-02-15info:eu-repo/semantics/openAccess37987826