Dang, My-Trang T.Gu, ChenyangKlavanian, Jeannie I.Jernigan, Katherine A.Friderici, Karen H.Cui, YuehuaMolina Molina, MaríaAncochea Bermúdez, JulioXaubet Mir, AntonioUhal, Bruce D.2018-11-272018-11-272013-08https://hdl.handle.net/2445/126454Single nucleotide polymorphisms (SNPs) in angiotensinogen (AGT) at positions -20 and -6 are associated with increased severity and progression of various fibrotic diseases. Our earlier work demonstrated that the progression of idiopathic pulmonary fibrosis (IPF) was associated with the A-6 allele. This study examined the hypothesis that the homozygous CC genotype at -20 and the AA genotype at -6 would confer worse measures of pulmonary function (measured by pulmonary function tests) in IPF. Multiple logistic regression analysis was applied to a NIH Lung Tissue Research Consortium cohort and a Spanish cohort, while also adjusting for covariates to determine the effects of these SNPs on measures of pulmonary function. Analysis demonstrated that the CC genotype at -20 was strongly associated with reduced diffusing capacity in males in both cohorts (p = 0.0028 for LTRC and p = 0.017 for the Spanish cohort). In females, the AA genotype was significantly associated with lower FVC (p = 0.0082) and V (alv) (p = 0.022). In males, the haplotype CA at -20 and -6 in AGT was also strongly associated with reduced diffusing capacity in both cohorts. This study is the first to demonstrate an association of AGT polymorphisms (-20A > C and -6G > A) with lower measures of pulmonary function in IPF. It is also the first to relate the effect of gender in lung fibrosis with polymorphisms in AGT.15 p.application/pdfeng(c) Springer, 2013AngiogènesiMalalties del pulmóNeovascularizationPulmonary diseasesinfo:eu-repo/semantics/article2018-07-24info:eu-repo/semantics/openAccess23715995