Palacín, ArantxaGómez Casado, CristinaRivas, Luis A.Aguirre, JacoboTordesillas, LeticiaBartra Tomàs, JoanBlanco, CarlosCarrillo, TeresaCuesta Herranz, JavierFrutos, Consolación deGarcía Álvarez-Eire, GenovevaFernández, Francisco J.Gamboa, PedroMuñoz, RosaSánchez-Monge, RosaSirvent, SofíaTorres, María J.Varela Losada, SusanaRodríguez, RosalíaParro, VictorBlanca, MiguelSalcedo, GabrielDíaz Perales, Araceli2018-09-192018-09-192012-12-141932-6203https://hdl.handle.net/2445/124688The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens.10 p.application/pdfengcc-by (c) Palacín, Arantxa et al., 2012http://creativecommons.org/licenses/by/3.0/esAl·lèrgensProteïnes vegetalsImmunologiaAllergensPlant proteinsImmunologyinfo:eu-repo/semantics/article6364292018-09-19info:eu-repo/semantics/openAccess23272072