Facile synthesis of azocino[4,3-b]indoles by ring-closing metathesis

Bennasar Fèlix, M. LluïsaZulaica Gallego, EsterSolé Arjó, DanielAlonso Serrano, Sandra2020-05-152020-05-152007-010040-4020https://hdl.handle.net/2445/160425The azocino[4,3-b]indole system, tricyclic substructure of the indole alkaloids apparicine and ervaticine, is efficiently assembled by ring-closing metathesis of 2-allyl-3-(allylaminomethyl)indoles. The metathesis sites are introduced into the indole nucleus by reductive amination of a 3-formyl derivative with allylamine, followed by a-lithiation with subsequent electrophilic trapping with acrolein.6 p.application/pdfeng(c) Elsevier B.V., 2007AlcaloidesMetàtesi (Química)Síntesi orgànicaAlkaloidsMetathesis (Chemistry)Organic synthesisFacile synthesis of azocino[4,3-b]indoles by ring-closing metathesisinfo:eu-repo/semantics/article5559232020-05-15info:eu-repo/semantics/openAccess