González Juanatey, CarlosAnguita Sánchez, ManuelBarrios, VivencioNúñez Gil, IvánGómez Doblas, Juan JoséGarcía Moll, XavierLafuente Gormaz, CarlosRollán Gómez, María JesúsPeral Disdier, VicenteMartínez Dolz, LuisRodríguez Santamarta, MiguelViñolas Prat, XavierSoriano Colomé, ToniMuñoz Aguilera, RobertoPlaza, IgnacioCurcio Ruigómez, AlejandroOrts Soler, ErnestoSegovia Cubero, JavierFanjul, VíctorMarín Corral, JudithCequier, ÁngelSavana Research Group2023-09-212023-09-212023-08-102077-0383https://hdl.handle.net/2445/202131Patients with type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) without myocardial infarction (MI) or stroke are at high risk for major cardiovascular events (MACEs). We aimed to provide real-world data on age-related clinical characteristics, treatment management, and incidence of major cardiovascular outcomes in T2DM-CAD patients in Spain from 2014 to 2018. We used EHRead (R) technology, which is based on natural language processing and machine learning, to extract unstructured clinical information from electronic health records (EHRs) from 12 hospitals. Of the 4072 included patients, 30.9% were younger than 65 years (66.3% male), 34.2% were aged 65-75 years (66.4% male), and 34.8% were older than 75 years (54.3% male). These older patients were more likely to have hypertension (OR 2.85), angina (OR 1.64), heart valve disease (OR 2.13), or peripheral vascular disease (OR 2.38) than those aged <65 years (p < 0.001 for all comparisons). In general, they were also more likely to receive pharmacological and interventional treatments. Moreover, these patients had a significantly higher risk of MACEs (HR 1.29; p = 0.003) and ischemic stroke (HR 2.39; p < 0.001). In summary, patients with T2DM-CAD in routine clinical practice tend to be older, have more comorbidities, are more heavily treated, and have a higher risk of developing MACE than is commonly assumed from clinical trial data.23 p.application/pdfengcc by (c) González Juanatey, Carlos et al., 2023http://creativecommons.org/licenses/by/3.0/es/Complicacions de la diabetisMalalties coronàriesPersones gransDiabetes complicationsCoronary diseasesOlder peopleinfo:eu-repo/semantics/article2023-09-18info:eu-repo/semantics/openAccess37629262