Rojo, PepRiera i Escalé, AntoniVerdaguer i Espaulella, Xavier2025-02-142025-02-142023-04-210010-8545https://hdl.handle.net/2445/218806Since the development of BisP* ligand by Imamoto, P-stereogenic phosphines bearing a bulky tert-butyl group and a smaller alkyl group have demonstrated extraordinary proficiency in a wide range of asymmetric processes. Over time, this class of ligands has brought about the introduction of more rigid backbones, the three-hindered quadrant concept, and the substitution of the tert-butyl group by adamantyl. The tert-butyl methyl fragment has also been introduced in phosphino-oxazoline-type ligands, and chemists in the industrial sector have also contributed to the evolution of this class of ligands by reporting the first successful P-stereogenic Buchwald-type monophosphines for asymmetric coupling reactions. The present review covers the synthesis and applications of bulky P-stereogenic phosphines that have been developed since the advent of BisP* in the late 1990s, with a special emphasis on ligands that have been successfully applied in asymmetric catalysis.34 p.application/pdfengcc-by-nc-nd (c) Rojo, Pep, et al., 2023http://creativecommons.org/licenses/by-nc-nd/4.0/OxidacióCatàlisiQuiralitatOxidationCatalysisChiralityinfo:eu-repo/semantics/article7394722025-02-14info:eu-repo/semantics/openAccess