Rudilla Mateo, HéctorFusté i Domínguez, EsterCajal Visa, YolandaRabanal Anglada, FrancescVinuesa Aumedes, TeresaViñas, Miquel2016-11-022016-11-022016-09-121420-3049https://hdl.handle.net/2445/103103The aim was to explore the antimicrobial activity of a synthetic peptide (AMP38) and its synergy with imipenem against imipenem-resistant Pseudomonas aeruginosa. The main mechanism of imipenem resistance is the loss or alteration of protein OprD. Time-kill and minimal biofilm eradication concentration (MBEC) determinations were carried out by using clinical imipenem-resistant strains. AMP38 was markedly synergistic with imipenem when determined in imipenem-resistant P. aeruginosa. MBEC obtained for the combination of AMP38 and imipenem was of 62.5 μg/mL, whereas the MBEC of each antimicrobial separately was 500 μg/mL. AMP38 should be regarded as a promising antimicrobial to fight MDR P. aeruginosa infections. Moreover, killing effect and antibiofilm activity of AMP38 plus imipenem was much higher than that of colistin plus imipenem.12 p.application/pdfengcc-by (c) Rudilla, Héctor et al., 2016http://creativecommons.org/licenses/by/3.0/esPseudomonasSíntesi de pèptidsPèptidsBiofilmsAntibiòticsPseudomonasPeptide synthesisPeptidesBiofilmsAntibioticsinfo:eu-repo/semantics/article6639692016-11-02info:eu-repo/semantics/openAccess27626405