Martínez Moreno, RebeccaPérez Serra, AlexandraCarreras, DavidAran Corbella, BegoñaKuebler, BerndBrugada, RamonScornik, Fabiana S.Pérez, Guillermo J.Selga i Coma, Elisabet2022-05-232022-05-232022-02-011873-5061https://hdl.handle.net/2445/185901The effects of genetic mutations on protein function can be studied in a physiologically relevant environment using tissue-specific cells differentiated from patient-derived induced pluripotent stem cells (iPSC). However, it is crucial to use iPSC derived from healthy individuals as control. We generated an iPS cell line from skin fibroblasts of a healthy Caucasian male by nucleofection of non-integrating episomal vectors. This cell line has normal karyotype, expresses pluripotency surface markers and pluripotency genes, and successfully differentiates into cells of the 3 germ layers. Therefore, it can be used as control for any disease of interest that is modelled using iPSC.5 p.application/pdfengcc by-nc-nd (c) Martínez Moreno, Rebecca et al, 2022http://creativecommons.org/licenses/by-nc-nd/3.0/es/FibroblastsSistemes de control biològicFibroblastsBiological control systemsinfo:eu-repo/semantics/article2022-05-19info:eu-repo/semantics/openAccess35231795