Casas Rodríguez, Rosa M.Urpí Sardà, MireiaSacanella Meseguer, EmilioArranz Martínez, SaraCorella Piquer, DoloresCastañer, OlgaLamuela Raventós, Rosa Ma.Salas Salvadó, JordiLapetra, JoséPortillo, María PuyEstruch Riba, Ramon2018-04-202018-04-202017-04-180962-9351https://hdl.handle.net/2445/121739Objective. To evaluate the long-Term effects of a Mediterranean diet (MeDiet) intervention on the plasma concentrations of inflammatory and plaque stability-related molecules in elderly people at high risk for cardiovascular disease. Design and Setting. 66 participants from primary care centers affiliated with the Hospital Clinic of Barcelona were randomized into 3 groups: MeDiet plus extra virgin olive oil (EVOO) or nuts and a low-fat diet (LFD). At baseline and at 3 and 5 years, we evaluated the changes in the plasma concentrations of 24 inflammatory biomarkers related to the different stages of the atherosclerotic process by Luminex®. Results. At 3 and 5 years, both MeDiet groups showed a significant reduction of IL-6, IL-8, MCP-1, and MIP-1β (P<0.05; all) compared to LFD. IL-1β, IL-5, IL-7, IL-12p70, IL-18, TNF-α, IFN-γ, GCSF, GMCSF, and ENA78 (P<0.05; all) only decreased in the MeDiet+EVOO group and E-selectin and sVCAM-1 (P<0.05; both) in the MeDiet+nuts group. Conclusions. Long-Term adherence to MeDiet decreases the plasma concentrations of inflammatory biomarkers related to different steps of atheroma plaque development in elderly persons at high cardiovascular risk.application/pdfengcc-by (c) Casas, Rosa et al., 2017http://creativecommons.org/licenses/by/3.0/esCuina mediterràniaMalalties cardiovascularsMediterranean cookingCardiovascular diseasesinfo:eu-repo/semantics/article6729472018-04-20info:eu-repo/semantics/openAccess28484308