Diastereoselective and catalytic α-alkylation of chiral N-acyl thiazolidinethiones with stable carbocationic salts

Kennington, Stuart C. D.Ferré, LauraRomo Fernández, Juan ManuelRomea, PedroUrpí Tubella, FèlixFont Bardia, Ma. Mercedes2019-03-042019-03-042017-06-150022-3263https://hdl.handle.net/2445/129477Direct nickel-catalyzed alkylation of chiral N-acyl-4-isopropyl-1,3-thiazolidine-2-thiones using a commercially available nickel(II) complex, (Me3P)2NiCl2, has been developed for tropylium and trityl tetrafluoroborate salts. The reaction provides a single diastereomer of the corresponding adducts in good to high yields, which, in turn, can be easily converted into a wide array of enantiomerically pure compounds that are difficult to obtain by other asymmetric procedures.8 p.application/pdfeng(c) American Chemical Society , 2017CatàlisiNíquelQuiralitatCatalysisNickelChiralityDiastereoselective and catalytic α-alkylation of chiral N-acyl thiazolidinethiones with stable carbocationic saltsinfo:eu-repo/semantics/article6727792019-03-04info:eu-repo/semantics/openAccess28525716