García Gasalla, MercedesPérez-Recio, SandraGrijota Camino, Mª de los DesamparadosAnibarro, LuisRabuñal Rey, RamónSabrià, JosefinaGijón-Vidaurreta, PalomaPomar, VirginiaDomínguez-Castellano, ÁngelTrigo, MatildeSantos, María JesúsCebollero, AlbaRodríguez, SaraMoga, EstherPenas-Truque, AntonMartos, CarmenRuiz-Serrano, María J.García de Cara, Erika InésAlcaide Fernández de Vega, FernandoSantín Cerezales, Miguel2024-03-052024-03-052023-08-301932-6203https://hdl.handle.net/2445/208412Background: Interferon-y Release Assays (IGRA) reversions have been reported in different clinical scenarios for the diagnosis of tuberculosis (TB) infection. This study aimed to determine the rate of QuantiFERON-TB Gold Plus (QFT-Plus) reversions during contact investigation as a potential strategy to reduce the number of preventive treatments. Methods: Prospective, multicentre cohort study of immunocompetent adult contacts of patients with pulmonary TB tested with QFT-Plus. Contacts with an initial positive QFT-Plus (QFT-i) underwent a second test within 4 weeks (QFT-1), and if negative, underwent a repeat test 4 weeks later (QFT-2). Based on the QFT-2 result, we classified cases as sustained reversion if they remained negative and as temporary reversion if they turned positive. Results: We included 415 contacts, of whom 96 (23.1%) had an initial positive test (QFT-i). Following this, 10 had negative QFT-1 results and 4 (4.2%) of these persisted with a negative result in the QFT-2 (sustained reversions). All four sustained reversions occurred in contacts with IFN-γ concentrations between ≥0.35 and ≤0.99 IU•mL-1 in one or both QFT-i tubes. Conclusion: In this study, TB contact investigations rarely reveal QFT-Plus reversion. These results do not support retesting cases with an initial positive result to reduce the number of preventive treatments.8 p.application/pdfengcc-by (c) Pérez-Recio, S. et al., 2023http://creativecommons.org/licenses/by/4.0/TuberculosiMedicina preventivaAdultsTuberculosisPreventive medicineAdulthoodinfo:eu-repo/semantics/article7425432024-03-05info:eu-repo/semantics/openAccess37647315