Ibáñez Sanz, GemmaDíez Villanueva, AnnaAlonso Aguado, Maria HenarRodríguez Moranta, FranciscoPérez Gómez, BeatrizBustamante Pineda, MarionaMartín Sánchez, VicenteLlorca Díaz, JavierAmiano, PilarArdanaz, EvaTardón, AdoninaJiménez Moleón, José JuanPeiró Pérez, RosanaAlguacil, JuanNavarro Sánchez, CarmenGuinó, ElisabetBinefa i Rodríguez, GemmaFernández Navarro, PabloEspinosa Cardiel, AnaDávila Batista, VerónicaMolina de la Torre, Antonio JoséPalazuelos-Calderón, CamiloAragonès Sanz, NúriaKogevinas, ManolisPollán, MarinaMoreno Aguado, Víctor2019-02-062019-02-062017-02-242045-2322https://hdl.handle.net/2445/127968Aquest article conté una errata annexadaColorectal cancer (CRC) screening of the average risk population is only indicated according to age. We aim to elaborate a model to stratify the risk of CRC by incorporating environmental data and single nucleotide polymorphisms (SNP). The MCC-Spain case-control study included 1336 CRC cases and 2744 controls. Subjects were interviewed on lifestyle factors, family and medical history. Twenty-one CRC susceptibility SNPs were genotyped. The environmental risk model, which included alcohol consumption, obesity, physical activity, red meat and vegetable consumption, and nonsteroidal anti-inflammatory drug use, contributed to CRC with an average per factor OR of 1.36 (95% CI 1.27 to 1.45). Family history of CRC contributed an OR of 2.25 (95% CI 1.87 to 2.72), and each additional SNP contributed an OR of 1.07 (95% CI 1.04 to 1.10). The risk of subjects with more than 25 risk alleles (5th quintile) was 82% higher (OR 1.82, 95% CI 1.11 to 2.98) than subjects with less than 19 alleles (1st quintile). This risk model, with an AUROC curve of 0.63 (95% CI 0.60 to 0.66), could be useful to stratify individuals. Environmental factors had more weight than the genetic score, which should be considered to encourage patients to achieve a healthier lifestyle.12 p.application/pdfengcc-by (c) Ibáñez Sanz, Gemma et al., 2017http://creativecommons.org/licenses/by/3.0/esCàncer colorectalEspanyaGenèticaEpidemiologiaInfluència del medi ambient en l'homeFactors de risc en les malaltiesColorectal cancerSpainGeneticsEpidemiologyEnvironmental effects on human beingsRisk factors in diseasesinfo:eu-repo/semantics/article6714762019-02-06info:eu-repo/semantics/openAccess28233817