Peters, SusanGallo, ValentinaVineis, PaoloMiddleton, Lefkos T.Forsgren, LarsSacerdote, CarlottaSieri, SabinaKyrozis, AndreasChirlaque, María DoloresZamora-Ros, RaulHansson, OskarPetersson, JesperKatzke, VerenaKühn, TilmanMokoroa, OlatzMasala, GiovannaArdanaz, EvaPanico, SalvatoreBergmann, Manuela M.Key, Timothy J.Weiderpass, ElisabeteFerrari, PietroVermeulen, Roel2021-02-232021-02-232020-05-01https://hdl.handle.net/2445/174212Background: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive. Objective: To assess the associations between alcohol consumption and PD risk. Methods: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence. Results: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5-29.9 g/day) were at ~50% higher risk compared with light consumption (0.1-4.9 g/day), but no linear exposure-response trend was observed. Analyses by beverage type also revealed no associations with PD. Conclusion: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.6 p.application/pdfengcc by (c) Peters et al., 2020http://creativecommons.org/licenses/by/3.0/es/Malaltia de ParkinsonConsum d'alcoholParkinson's diseaseDrinking of alcoholic beveragesinfo:eu-repo/semantics/article2021-02-18info:eu-repo/semantics/openAccess32357270