Artzi-Medvedik, RadaKob, RobertDi Rosa, MirkoLattanzio, FabriziaCorsonello, AndreaYehoshua, IlianRoller-Wirnsberger, ReginaWirnsberger, GerhardMattace-Raso, FrancescoTap, LisanneGil, PedroFormiga Pérez, FrancescMoreno-Gonzalez, RafaelKostka, TomaszGuligowska, AgnieszkaÄrnlöv, JohanCarlsson, Axel C.Freiberger, EllenMelzer, Itshak2023-06-162023-06-162023-05-112077-0383https://hdl.handle.net/2445/199405Abstract: A longitudinal alteration in health-related quality of life (HRQoL) over a two-year period and its association with early-stage chronic kidney disease (CKD) progression was investigated among 1748 older adults (>75 years). HRQoL was measured by the Euro-Quality of Life Visual Analog Scale (EQ-VAS) at baseline and at one and two years after recruitment. A full comprehensive geriatric assessment was performed, including sociodemographic and clinical characteristics, the Geriatric Depression Scale-Short Form (GDS-SF), Short Physical Performance Ba􀁀ery (SPPB), and estimated glomerular filtration rate (eGFR). The association between EQ-VAS decline and covariates was investigated by multivariable analyses. A total of 41% of the participants showed EQ-VAS decline, and 16.3% showed kidney function decline over the two-year follow-up period. Participants with EQ-VAS decline showed an increase in GDS-SF scores and a greater decline in SPPB scores. The logistic regression analyses showed no contribution of a decrease in kidney function on EQVAS decline in the early stages of CKD. However, older adults with a greater GDS-SF score were more likely to present EQ-VAS decline over time, whereas an increase in the SPPB scores was associated with less EQ-VAS decline. This finding should be considered in clinical practice and when HRQoL is used to evaluate health interventions among older adults.14 p.application/pdfengcc-by (c) Artzi-Medvedik, Rada et al., 2023https://creativecommons.org/licenses/by/4.0/Malalties del ronyóPersones gransQualitat de vidaKidney diseasesOlder peopleQuality of lifeinfo:eu-repo/semantics/article7355752023-06-16info:eu-repo/semantics/openAccess