Calon, AlexandreEspinet, ElisaPalomo Ponce, SergioTauriello, Daniele V. F.Iglesias, MarCespedes, María VirtudesSevillano, MartaNadal, CristinaJung, PeterZhang, Xiang H. F.Byrom, DanielRiera i Escalé, AntoniRossell, DavidMangues, RamonMassagué i Solé, Joan, 1953-Sancho, ElenaBatlle, Eduard2022-02-242022-02-242014-03-052331-8325https://hdl.handle.net/2445/183467We sought to understand the mechanisms behind the potent effect of stromal TGF-beta program on the capacity of colorectal cancer (CRC) cells to initiate metastasis. We discovered that mice subcutaneous tumors and metastases generated in the context of a TGF-beta activated microenvironment displayed prominent accumulation of p-STAT3 in CRC cells compared with those derived from control cells. STAT3 signaling depended on GP130 as shown by strong reduction of epithelial p STAT3 levels upon GP130 shRNA-mediated knockdown in CRC cells.4 p.application/pdfeng(c) Bio-protocol LLC, 2014Càncer colorectalMetàstasiExpressió gènicaColorectal cancerMetastasisGene expressioninfo:eu-repo/semantics/article2022-02-24info:eu-repo/semantics/openAccess6544612