Camprubí, DanielGomila Grange, AinaGrijota Camino, Mª de los DesamparadosSoldevila-Boixader, LauraLuque, Maria J.Alcaide Fernández de Vega, FernandoDorca i Sargatal, JordiSantín Cerezales, Miguel2023-12-012023-12-012020-030163-4453https://hdl.handle.net/2445/204083Currently, pulmonary tuberculosis (TB) isolation recommendations are based on serial sputum smear microscopy. To assess infectiousness of smear-negative/GeneXpert-positive (Sm-/GXpert+) pulmonary TB, we evaluated 511 contacts of pulmonary TB patients attended at a teaching hospital in Spain (2010-2018). There were no statistically significant differences in rates of Mycobacterium tuberculosis infection (46.2% contacts of smear-positive and 34.6% contacts of Sm-/GXpert+ pulmonary TB patients, p=0.112). Sm-/GXpert+ pulmonary TB poses a substantial risk of transmission of M. tuberculosis infection. Our results add evidence to support including Real-time Polymerase Chain Reaction (Xpert®MTB/RIF) in the work-up diagnosis of suspected pulmonary TB cases to make decisions on air-borne isolation.3 p.application/pdfengcc-by-nc-nd (c) The British Infection Association, 2020http://creativecommons.org/licenses/by-nc-nd/4.0/TuberculosiReacció en cadena de la polimerasaTuberculosisPolymerase chain reactioninfo:eu-repo/semantics/article6957862023-12-01info:eu-repo/semantics/openAccess31954744