Santacana, MartiArias Sampériz, BárbaraMitjans Niubó, MarinaBonillo, AlbertMontoro, MariaRosado, SilviaGuillamat, RoserVallès, VicençPérez, VíctorForero, Carlos G.Fullana Rivas, Miguel Àngel2017-06-062017-06-062016-06-291932-6203https://hdl.handle.net/2445/112016BACKGROUND: Anxiety disorders are highly prevalent and result in low quality of life and a high social and economic cost. The efficacy of cognitive-behavioural therapy (CBT) for anxiety disorders is well established, but a substantial proportion of patients do not respond to this treatment. Understanding which genetic and environmental factors are responsible for this differential response to treatment is a key step towards 'personalized medicine'. Based on previous research, our objective was to test whether the BDNF Val66Met polymorphism and/or childhood maltreatment are associated with response trajectories during exposure-based CBT for panic disorder (PD). METHOD: We used Growth Mixture Modeling to identify latent classes of change (response trajectories) in patients with PD (N = 97) who underwent group manualized exposure-based CBT. We conducted logistic regression to investigate the effect on these trajectories of the BDNF Val66Met polymorphism and two different types of childhood maltreatment, abuse and neglect. RESULTS: We identified two response trajectories ('high response' and 'low response'), and found that they were not significantly associated with either the genetic (BDNF Val66Met polymorphism) or childhood trauma-related variables of interest, nor with an interaction between these variables. CONCLUSIONS: We found no evidence to support an effect of the BDNF gene or childhood trauma-related variables on CBT outcome in PD. Future studies in this field may benefit from looking at other genotypes or using different (e.g. whole-genome) approaches.14 p.application/pdfengcc-by (c) Santacana, Marti et al., 2016http://creativecommons.org/licenses/by/3.0/esAnsietatTrastorns de pànicMaltractament infantilGenètica humanaPolimorfisme genèticAnxietyPanic disordersChild abuseHuman geneticsGenetic polymorphismsinfo:eu-repo/semantics/article6688092017-06-06info:eu-repo/semantics/openAccess27355213