Fort Aznar, LauraMolina Porcel, LauraRamos Campoy, OscarEsteller Gauxax, DianaNaranjo, LauraLladó Plarrumaní, AlbertBalasa, MirceaRuiz García, RaquelAntonell Boixader, Anna, 1978-Sánchez del Valle Díaz, Raquel2024-04-242024-04-242024-01-121387-2877https://hdl.handle.net/2445/210362We analyzed Lewy body (LB) pathology in 18 autosomal dominant Alzheimer's disease (ADAD) brains via immunohistochemistry. Real-time quaking induced conversion was used to detect misfolded α-synuclein (α-syn) in 18 living ADAD cerebrospinal fluid (CSF) samples. Concomitant LB pathology was present in 44% ADAD brains. Only 6% CSF samples were positive for misfolded α-syn. In an additional AD sample, all patients with confirmed LB presented misfolded α-syn in postmortem CSF regardless of the LB staging. In conclusion, misfolded α-syn in CSF was scarce in symptomatic living ADAD individuals, in contrast to postmortem brain tissue. These results suggest late appearance of LB pathology in ADAD.24 p.application/pdfeng(c) IOS Press, 2023Malaltia d'AlzheimerProteïnesAlzheimer's diseaseProteinsinfo:eu-repo/semantics/preprint2024-04-24info:eu-repo/semantics/openAccess938321338250774