Suárez Lledó, AnaLlop Talaveron, Josep M.Leiva Badosa, ElisabetFarran Teixido, LeandreMiró Martín, MónicaBas Minguet, JordiNavarro Velázquez, SergioCreus Costas, GloriaVirgili Casas, NuriaFernández Álvarez, MónicaBadía Tahull, María B.2024-02-232024-02-232023-12-212072-6643https://hdl.handle.net/2445/207993(Background) Esophagectomy (EPG) presents high morbidity and mortality. Omega-3 fatty acids (omega-3FA) are a pharmaconutrient with benefits for postoperative morbidity. Studies of omega-3FA administered parenterally after esophagectomy are scarce. This study proposes to investigate the effect of combining fish oil lipid emulsions (LE) administered parenterally with enteral nutrition support. (Methods) Randomization was 1:1:1 in three groups: Group A received a LE mixture of 0.4 g/kg/day of fish oil and 0.4 g/kg/day of LCT/MCT 50:50, Group B received 0.8 g/kg/day of fish oil LE, and Group C received 0.8 g/kg/day of LCT/MCT 50:50. Variables were measured at recruitment time and day +1, +3, and +5. Inflammatory variables studied were Interlukin-6, C-reactive protein (CRP), tumoral necrosis factor-alpha (TNF-alpha), IL-10, IL-8 and CD25s. Safety, nutritional parameters and complications were analyzed. (Results) Administration of omega-3LE in the immediate postoperative period did not modulate the earlier inflammatory response. Statistically significant differences were found in IL-6 and CRP overall temporal evolution but were not found when studying the type of LE administered or in patients needing critical care. Administration of omega-3 resulted in safe and improved hypertriglyceridemia, depending on the dose. (Conclusions) omega-3FA has no impact on the early inflammatory postoperative response assessed for a short period but was safe. More studies for longer periods are needed.12 p.application/pdfengcc by (c) Suárez Lledó, Ana et al, 2023http://creativecommons.org/licenses/by/3.0/es/Suplements nutritiusEmulsionsDietary supplementsEmulsionsinfo:eu-repo/semantics/article2024-01-29info:eu-repo/semantics/openAccess38201870