Mesquida, MarinaMolins Monteys, BlancaLlorenç, VictorSainz de la Maza Serra, María TeresaHernandez, Maria VictoriaEspinosa Garriga, GerardAdán Civera, Alfredo2018-02-082018-02-082014-06-080962-9351https://hdl.handle.net/2445/119678The aim of the present study was to determine the serum cytokine profile and levels of high sensitivity C-reactive protein (hsCRP) in patients with uveitis associated with Behcet's disease (BD) and to compare them with those obtained from healthy control subjects. We determined the serum concentration of interferon-gamma (IFN-gamma), interleukin-1 beta (IL-1 beta), IL-12p70, IL-17A, tumor necrosis factor-alpha (TNF-alpha), and hsCRP in 13 patients with active uveitis associated to BD, 24 inactive BD patients, and 20 controls. In a subgroup of 10 active patients, a second serum sample was obtained when the disease was inactive. Cytokine profiles and hsCRP levels were correlated with disease activity, severity, complications, and visual outcome. Levels of IFN-gamma and TNF-alpha were significantly increased in patients with active uveitis associated to BD compared to controls (P < 0.05). IFN-gamma, TNF-alpha, and hsCRP were significantly higher during active uveitis associated to BD compared to inactive disease (P < 0.05). Furthermore, IL-17A was significantly increased in patients with active BD without pharmacological treatment compared to controls (P < 0.05). No significant correlations were found with specific cytokine profiles and disease severity, visual outcome, or complications. In summary, increased serum levels of IFN-gamma, TNF-alpha, IL-17A, and hsCRP were associated with active uveitis associated with BD and might serve as markers of disease activity.9 p.application/pdfengcc-by (c) Mesquida, Marina et al., 2014http://creativecommons.org/licenses/by/3.0/esCitoquinesProteïnes de la sangUveïtisMalaltia de BehçetInflamacióCytokinesBlood proteinsUveitisBehçet's diseaseInflammationinfo:eu-repo/semantics/article6637862018-02-08info:eu-repo/semantics/openAccess24994946