Torres-Novellas, BertaGuayta, Rafael (Guayta Escolies)Rius, PilarCastellà, AmparoGascón Lecha, M. PilarModamio Charles, PilarMariño Hernández, Eduardo L.2026-01-272026-01-272021https://hdl.handle.net/2445/226216The prevalence of elderly patients with chronic illnesses, associated polypharmacy and a high risk of functional and cognitive impairment has increased in recent</p><p>years. The care of Complex Chronic Patients (CCP) therefore represents a challenge for health systems in developed countries around the world. This paper presents</p><p>a study protocol that will explore the effects of an intervention within a pharmaceutical care programme (PCAF) on optimising CCP care and on the suitability of</p><p>the organisational methods proposed for the PCAF programme.</p><p>This is a multicentre experimental study. The setting will be primary health care and community pharmacies in the so-called ‘autonomous community’ of Catalonia</p><p>in Spain. The participants will be CPP attended to Primary Healthcare Centres with the CCP code in their electronic medical record. The included CCP will be</p><p>distributed in two strata depending on whether they will be considered likely to receive the arranged medicinal treatment as Monitored Dosage System according</p><p>to benefits based on criteria or not. They will then be assigned by random stratified sampling at a ratio of 1:1 to the control or intervention groups. A sample size of</p><p>860 patients is estimated. Patients will undergo 12 months follow-up. The primary outcome of this study will be the medication adherence measured by the Morisky</p><p>Green Test and the billing/prescription ratio.5 p.application/pdfengcc-by (c) Torres-Novellas, B. et al., 2021http://creativecommons.org/licenses/by/4.0/Malalties cròniquesAtenció farmacèuticaChronic diseasesPharmacy practiceinfo:eu-repo/semantics/article7105652026-01-27info:eu-repo/semantics/openAccess