Castro Quintas, ÁguedaPalma-Gudiel, HelenaSan Martín-Gonzalez, NereaCaso, Javier R.Leza, Juan C.Fañanás Saura, Lourdes2023-07-282023-07-282023-07-210091-3022https://hdl.handle.net/2445/201299Mucosal secretory immunoglobulin A (s-IgA) has been recognized as a key component of human first line defense against infection. However, its reactivity to psychosocial stressors is poorly understood. This systematic review aimed to explore whether s-IgA levels changed after psychosocial stress in subjects under the age of 18. Fifteen articles were included. s-IgA basal levels are increased in children older than 9 years old exposed to stress. Furthermore, s-IgA seems to follow a circadian rhythm, which is altered under stress conditions. Finally, the collective evidence suggests that salivary s-IgA rapidly increases under acute stress after puberty. Overall, our review indicates that s-IgA could be considered a potential psychosocial stress biomarker of interest for pediatric and child-juvenile psychiatric population. Further studies are needed to validate the role of s-IgA circadian rhythm and basal levels as psychosocial stress biomarkers and disentangle the role of age and type of stressor.16 p.application/pdfengcc-by-nc-nd (c) Castro-Quintas, Águeda et al., 2023https://creativecommons.org/licenses/by-nc-nd/4.0/Estrès (Psicologia)Ritmes circadiarisInfànciaAdolescènciaResposta immunitàriaStress (Psychology)Circadian rhythmsChildhoodAdolescenceImmune responseinfo:eu-repo/semantics/article7382102023-07-28info:eu-repo/semantics/openAccess