Sequential ring-closing metathesis-vinyl halide Heck cyclization reactions: access to the tetracyclic ring system of ervitsine

Bennasar Fèlix, M. LluïsaZulaica Gallego, EsterSolé Arjó, DanielAlonso Serrano, Sandra2020-06-042020-06-042012-06-170040-4020https://hdl.handle.net/2445/164274A chemoselective indole-templated ring-closing metathesis is used to assemble the cyclohepta[b]indole substructure of the indole alkaloid ervitsine. A subsequent intramolecular Heck coupling of the resulting alkene functionality with an amino-tethered vinyl halide accomplishes the closure of the unique 2- azabicyclo[4.3.1]decane framework of the alkaloid with concomitant incorporation of the exocyclic Eethylidene substituent.8 p.application/pdfeng(c) Elsevier B.V., 2012Metàtesi (Química)Reaccions químiquesProductes naturalsSíntesi orgànicaAlcaloidesMetathesis (Chemistry)Chemical reactionsNatural productsOrganic synthesisAlkaloidsSequential ring-closing metathesis-vinyl halide Heck cyclization reactions: access to the tetracyclic ring system of ervitsineinfo:eu-repo/semantics/article6226912020-06-04info:eu-repo/semantics/openAccess