Mena Cervigón, MarisaFrias Gomez, JonTaberna, MirenQuirós, BeatrizMarquez, SandraClavero, OmarBaena, A.Lloveras Rubio, BetlemAlejo, MariaLeón, X.García, J.Mesía Nin, RicardBermejo, O.Bonfill, T.Aguilà, AntonGuix, M.Hijano, R.Pavón Ribas, Miquel ÀngelTorres, M.Tous, SaraClèries Soler, RamonAlemany i Vilches, Laia2020-11-032020-11-032020-08-06https://hdl.handle.net/2445/171705The incidence of human papillomavirus (HPV)-related oropharyngeal cancer is increasing in some regions. Nevertheless, the epidemiology of this disease has not been extensively investigated in southern Europe. We conducted a retrospective cohort study of patients diagnosed with primary oropharyngeal cancer from 1991 to 2016. Cancer tissues underwent histopathological evaluation, DNA quality control, HPV-DNA detection and p16INK4a immunohistochemistry. Data were collected from medical records. Factors associated with HPV positivity and time trends were evaluated with multivariable Bayesian models. The adjusted prevalence of HPV-related cases in 864 patients with a valid HPV-DNA result was 9.7%, with HPV-DNA/p16INK4a double positivity being considered. HPV-related oropharyngeal cancer was likely to occur in non-smokers and non-drinkers, to be located in the tonsil or diagnosed at advanced stages. Time-trend analysis showed an increasing risk of HPV-related oropharyngeal cancer in the most recent periods (5-year period increase of 30%). This increase was highest and with a clear increasing trend only in the most recent years (2012–2016). The prevalence of HPV-related oropharyngeal cancer started to sharply increase in the most recent years in our setting, as occurred two decades ago in areas where most oropharyngeal cancer cases are currently HPV-related. Our results provide a comprehensive assessment of the epidemiological landscape of HPV-related oropharyngeal cancer in a region of southern Europe.11 p.application/pdfengcc by (c) Mena Cervigón et al., 2019http://creativecommons.org/licenses/by/3.0/es/Papil·lomavirusCàncer de collEpidemiologiaPapillomavirusesNeck cancerEpidemiologyinfo:eu-repo/semantics/article7088502020-11-03info:eu-repo/semantics/openAccess32764593