Molina Jiménez, M. DoloresCebrià Sánchez, Francesc2023-02-142023-02-1420212218-273Xhttps://hdl.handle.net/2445/193594Planarians are flatworms capable of whole-body regeneration, able to regrow any missing body part after injury or amputation. The extraordinary regenerative capacity of planarians is based upon the presence in the adult of a large population of somatic pluripotent stem cells. These cells, called neoblasts, offer a unique system to study the process of stem cell specification and differentiation in vivo. In recent years, FACS-based isolation of neoblasts, RNAi functional analyses as well as high-throughput approaches such as single-cell sequencing have allowed a rapid progress in our understanding of many different aspects of neoblast biology. Here, we summarize our current knowledge on the molecular signatures that define planarian neoblasts heterogeneity, which includes a percentage of truly pluripotent stem cells, and guide the commitment of pluripotent neoblasts into lineage-specific progenitor cells, as well as their differentiation into specific planarian cell types.23 p.application/pdfengcc-by (c) Molina Jiménez, M. Dolores et al., 2021https://creativecommons.org/licenses/by/4.0/Cèl·lules mareRegeneració (Biologia)Stem cellsRegeneration (Biology)info:eu-repo/semantics/article7157802023-02-14info:eu-repo/semantics/openAccess