Ciruela Alférez, FranciscoSotelo, Eddy2018-05-022018-05-022017-07-201420-3049https://hdl.handle.net/2445/121982Nearly 90 years ago, Drury and Szent-Györgyi revealed that adenosine produced profound hypotension and bradycardia, and it affected kidney function in mammals [1]. Since then, the physiological role and potential therapeutic use of adenosine have been extensively explored [2,3]. Adenosine is considered a retaliatory metabolite [4], thus increasing oxygen supply and decreasing oxygen consumption.4 p.application/pdfengcc-by (c) Ciruela Alférez, Francisco et al., 2017http://creativecommons.org/licenses/by/3.0/esAdenosinaReceptors neuralsPurinesBatecs cardíacsAdenosineNeural receptorPurinesHeart beatinfo:eu-repo/semantics/article6794442018-05-02info:eu-repo/semantics/openAccess28726742