Dynamic Kinetic Resolution and Desymmetrization Processes: A Straightforward Methodology for the Enantioselective Synthesis of Piperidines

Amat Tusón, MercedesBassas Sapé, OriolLlor Brunés, NúriaCantó Espot, MargalidaPérez Bosch, MariaMolins i Grau, EliesBosch Cartes, Joan2020-05-282020-05-2820060947-6539https://hdl.handle.net/2445/162922A straightforward procedure for the synthesis of enantiopure polysubstituted piperidines is reported. It involves the direct generation of chiral non‐racemic oxazolo[3,2‐a ]piperidone lactams that already incorporate carbon substituents on the heterocyclic ring and the subsequent removal of the chiral auxiliary. The key step is a cyclocondensation reaction of (R )‐phenylglycinol or other amino alcohols with racemic or prochiral δ‐oxo (di)acid derivatives in highly stereoselective processes involving dynamic kinetic resolution and/or desymmetrization of diastereotopic or enantiotopic ester groups.139 p.application/pdfeng(c) Wiley-VCH, 2006Síntesi orgànicaAlcaloidesOrganic synthesisAlkaloidsDynamic Kinetic Resolution and Desymmetrization Processes: A Straightforward Methodology for the Enantioselective Synthesis of Piperidinesinfo:eu-repo/semantics/article5401372020-05-28info:eu-repo/semantics/openAccess