Meli, AlessandraTedesco, ConsigliaDella Sala, GiorgioSchettini, RosariaAlbericio Palomera, Fernandode Riccardis, FrancescoIzzo, Irene2020-04-272020-04-272017-03-181660-3397https://hdl.handle.net/2445/157647A critical summary on the discovery of the nineteen members of the phakellistatin family (phakellistatin 1-19), cytotoxic proline‐rich cyclopeptides of marine origin, is reported. Isolation, structural elucidation, and biological properties of the various‐sized natural macrocycles are described, along with the total syntheses and the enigmatic issues of the cytotoxic activity reproducibility.16 p.application/pdfengcc-by (c) Meli, Alessandra et al., 2017http://creativecommons.org/licenses/by/3.0/esAminoàcidsSíntesi de pèptidsFarmacologiaAmino acidsPeptide synthesisPharmacologyinfo:eu-repo/semantics/article6810902020-04-27info:eu-repo/semantics/openAccess28335479