Romero, M.Zanuy, M.Rosell, E.Cascante i Serratosa, MartaPiulats, Josep M.Font Bardia, Ma. MercedesBalzirini, J.de Clercq, E.Pujol Dilmé, M. Dolors2020-06-062020-06-062015-01-270223-5234https://hdl.handle.net/2445/164558The aqueous extraction of the sesquiterpene lactone xanthatin from Xanthium spinosum L. favours the conversion of xanthinium to xanthatin via the loss of acetic acid. The cytotoxic (Hep-G2 and L1210 human cell lines) and antiviral activities of isolated xanthatin are established. This natural compound shows significant cytotoxicity against the Hep-G2 cell line and our experimental results reveal its strong anti-angiogenesis capacity in vitro. The structure of xanthatin is determined by spectroscopic methods and for the first time confirmed by X-ray diffraction.26 p.application/pdfeng(c) Elsevier Masson SAS, 2015Plantes medicinalsMedicaments antivíricsRadiocristal·lografiaMedicinal plantsAntiviral agentsX-ray crystallographyinfo:eu-repo/semantics/article6484562020-06-06info:eu-repo/semantics/openAccess25481815