Gutierrez Bedmar, MarioMartínez-González, Miguel Ángel, 1957-Muñoz Bravo, CarlosRuiz Canela, MiguelMariscal, AlbertoSalas Salvadó, JordiEstruch Riba, RamonCorella Piquer, DoloresAros, FernandoFitó Colomer, MontserratLapetra, JoséSerra Majem, LluísPintó Sala, XavierAlonso Gómez, Ángel M.Portoles, OlgaFiol Sala, MiguelBulló, MònicaCastañer, OlgaRos Rahola, EmilioGomez-Gracia, Enrique2022-11-222022-11-222017-08-011346-9843https://hdl.handle.net/2445/191073Background: Epidemiological data on chromium (Cr) exposure and the risk of cardiovascular disease (CVD) are still limited. Toenail Cr level (TCL) provides a time-integrated measure reflecting long-term Cr exposure. We measured TCL to assess the hypothesis that long-term Cr exposure was inversely associated with incident CVD in a population at high risk for CVD.Methods and Results: The associations between TCL and CVD were evaluated in a case-control study nested within the 'PREvencion con Dleta MEDiterranea' (PREDIMED) trial. We randomly selected 147 of the 288 patients diagnosed with CVD during follow-up and matched them on age and sex to 271 controls. Instrumental neutron activation analysis was used to assess TCL. In-person interviews, medical record reviews, and validated questionnaires were used to assess covariates. The fully adjusted OR for the highest vs. lowest quartile of toenail Cr was 0.54 (95% CI: 0.26-1.14; P-trend=0.189) for the nested case-control study. On stratification for diabetes mellitus (DM), OR was 1.37 (95% CI: 0.54-3.46; P-trend=0.364) for the DM group, and 0.25 (95% CI: 0.08-0.80; P-trend=0.030) for the non-DM group (P for interaction=0.078).Conclusions: The present findings, although not statistically significant, are consistent with previously reported inverse associations between TCL and CVD. These results, especially for non-DM patients, increase the limited epidemiological knowledge about the possible protective role of Cr against CVD.8 p.application/pdfeng(c) Japanese Circulation Society, 2017Malalties cardiovascularsDiabetisDietaCuina mediterràniaCardiovascular diseasesDiabetesDietMediterranean cookinginfo:eu-repo/semantics/article6769752022-11-22info:eu-repo/semantics/openAccess28392547