Respiratory chain dysfunction associated with multiple mitochondrial DNA deletions in antiretroviral therapy-related lipodystrophy.

Miró i Andreu, ÒscarGómez, MontserratPedrol, EnricCardellach, FrancescNunes Martínez, VirginiaCasademont i Pou, Jordi2013-05-032013-05-032000-08-180269-9370https://hdl.handle.net/2445/41644Highly-active antiretroviral therapy (HAART) can induce a characteristic lipodystrophy syndrome characterized by peripheral fat wasting and central adiposity, usually associated with hyperlipidaemia and insulin resistance [1,2]. Indirect data have led some authors to propose that mitochondrial dysfunction could play a role in this syndrome [3,4].To date, as recently outlined by Kakuda et al. [5] in this journal, HIV-infected patients developing lipodystrophy have not been studied for mitochondrial changes or respiratory chain capacity...3 p.application/pdfeng(c) Lippincott Williams & Wilkins, 2000AntiretroviralsInfeccions per VIHAntiretroviral agentsHIV infectionsRespiratory chain dysfunction associated with multiple mitochondrial DNA deletions in antiretroviral therapy-related lipodystrophy.info:eu-repo/semantics/article1578922013-05-03info:eu-repo/semantics/openAccess10985326