Rodríguez Raurell, LauraAlfonso Rodríguez, IgnacioSintes Marcos, Miquel2014-07-142014-07-142014-06https://hdl.handle.net/2445/55774Treballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2014, Tutors: Dra. Laura Rodríguez Raurell i Dr. Ignacio Alfonso RodríguezThe aim of this work is the synthesis of the chiral pseudopeptidic macrocycle 5b and its use, together with analogue macrocycle 5a (Scheme 1) as ligands for Cu2+, in molecular recognition processes of amino acids. The two dinuclear complexes will be used as receptors in molecular recognition processes. The synthesis of the [2+2] pseudopeptidic macrocycle through a reductive amination is carried out by using an anionic template which places the four subunits in the right orientation for their union. The obtained product is characterized by ESI-MS and NMR. Copper complexes are prepared starting with the meta macrocycle and its para analogue. The resulting products are characterized by ESI MS. A comparative study of many amino acids and analogues behavior with the two macrocyclic complexes is carried out by UV-Vis spectrophotometry. After that, recognition tests are made with the two possible Malate isomers and association constants values are calculated for both isomers with macrocyclic copper complex.55 p.application/pdfengcc-by-nc-nd (c) Sintes Marcos, 2014http://creativecommons.org/licenses/by-nc-nd/3.0/es/Reconeixement molecularQuímica supramolecularTreballs de fi de grauMolecular recognitionSupramolecular chemistryBachelor's thesesinfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccess