Companys Alemany, JúliaRoig-Soriano, JoanTurcu, Andreea L.Chillón, MiguelVázquez Cruz, SantiagoPallàs i Llibería, Mercè, 1964-Griñán Ferré, Christian2022-10-062023-10-052022-10-050959-4965https://hdl.handle.net/2445/189684N-methyl-D-aspartate (NMDA) receptor antagonists mediate adult neurogenic effects. Here, the neurogenic effect of a new NMDA receptor antagonist endowed with neuroprotective effects in Alzheimer's disease mice model. Nine-month-old senescence-accelerated mouse prone 8 (SAMP8) with UB-ALT-EV were orally treated. 5-Bromo-2-deoxyuridine (BrdU) (50 mg/kg) was 3× injected I.P. every 2 h. After 28 days of treatment, SAMP8-treated group improved working memory. Moreover, the number of BrdU+ cells and DCX+ cells in the SAMP8 dentate gyrus (DG) was significantly increased. GFAP+ cells were not affected by treatment. Together, these results provided evidence that UB-ALT-EV promotes the survival and proliferation of neural progenitor cells in the aged SAMP8 hippocampus.6 p.application/pdfeng(c) Lippincott, Williams & Wilkins, 2022Hipocamp (Cervell)Malalties neurodegenerativesEnvellimentHippocampus (Brain)Neurodegenerative DiseasesAginginfo:eu-repo/semantics/article7246122022-10-06info:eu-repo/semantics/openAccess