Ceccato, AdrianForne, CarlesBos, Lieuwe D.Camprubí Rimblas, MartaAreny Balagueró, AinaCampaña Duel, ElenaQuero, SaraDiaz, EmiliRoca, OriolGonzalo Calvo, David deFernández Barat, LaiaBermejo, JesusMosquera Rodríguez, DavidPérez Bastida, LeireGonzalez, JesicaNicolás, José MaríaAdell Serrano, BertaRicart, PilarBarbe, FerranBáez Pravia, OrvilleGómez Casal, VanesaPozo, Juan CarlosCalfee, Carolyn S.Mamolar Herrera, NuriaVillada Warrington, TatianaAñon, Jose ManuelAlcaraz Serrano, VictoriaArtigas, AntonioNieto, María TeresaMartín Vicente, PaulaCarbajales Pérez, CristinaArrieta Ruiz, MartaBarral Segade, PatriciaGracia, Maria PilarMuñiz Albaiceta, GuillermoIglesias, SilviaBermejo Martin, Jesús F.Torres, GerardSánchez Miralles, AngelCarvalho, SulamitaValledor, ManuelHofstadt Martín-Montalvo, Maria van derRodríguez de Castro, FelipeRuiz García, Ángela LeonorCasacuberta Barberà, NúriaCarbonell, NievesCastellà Pericàs, ManuelNovo, Mariana AndreaCatalán González, MercedesSpeziale, CarlaRodriguez, LauraMontserrat, NeusEsmorís Arijón, InésPeñuelas, OscarRamon Coll, NúriaCastellví, AndreaSoliva, LauraIbarz, MercedesMantellini, Cecilia L.Cardina Fernández, PabloGarnacho Montero, JoséJorge García, Ruth NoemíBalsera, BegoñaGabarrús, AlbertFerrer, RicardMurúa, Pablo RyanSánchez, MiguelLópez Lago, AnaCastro, PedroKiarostami, KarsaBouza Vieiro, María TeresaTorres, MateuRodríguez Ruiz, CovadongaMartín Delgado, María CruzTorre, Maria del Carmen de laBarroso, MartaSerrano Lázaro, AinhoaFranco, NievesFerrando, CarlosÁlvarez, Juan IlazoYang, MinlanGómez, SilviaFigueras, AlbertForcadell Ferreres, EvaForcelledo Espina, LorenaMasa Jiménez, Juan FernandoGascón Castillo, Maria LuisaTormos, AdriánBusto Martínez, Cecilia delSuárez Sipmann, FernandoNaya, Gregorio MarcoUrrelo Cerrón, LuisSánchez, AnaCliment, CristinaMartínez Varela, IgnacioMuñoz Bermúdez, RosanaBlandino Ortiz, AaronGordo, FedericoRenedo Sánchez-Giron, GloriaMacias Guerrero, DesireFranquesa, EnricAndrea, RuthCruz Martin, MaríaHuerta, ArturoBueno, LeticiaSalazar Degracia, AnaSaborido Paz, EvaTrefler, SandraCiberesucicovid ProjectSagredo, VictorFurro, ÀngelsGomà, GemmaMartínez Fernández, Carmen EulaliaBustamante Munguira, ElenaRodríguez, AlejandroGarcia Gasulla, DarioPestaña Laguna, DavidEstella, AngelPérez García, FelipeMañezMendiluce, RafaelGonzalo Calvo, David deÚbeda, AlejandroPedregosa Díaz, JoseLópez Ramos, EstherBadia, Joan RamonÁlvarez Ruiz, AntonioTrenado Álvarez, JoséGarcía Sagastume, AmaiaRuiz Miralles, MiriamOrtiz, Aaron BlandinoMartínez Gándara, Amalia de laSánchez Miralles, AngelSariñena, Maria TeresaMariño, Ana BalanGarcía, BeatrizLópez Messa, JuanNogué Bou, RamonSolé Violán, JordiAlmansa, RaquelRiera, JordiAldecoa, CesarSalvador Adell, InmaculadaBalan Mariño, AnaNogueras Salinas, RafaelaBarbena, LauraBardi, TommasoOcón, MartaRivas Vilas, María DignaBoado, Maria VictoriaOrtega, AnaConde, PamelaFernández, JavierCaballero, JesúsSantacoloma, BitorMartínez Juan, Maria DoloresPrados, JavierBarberán, JoséOssa, SergioSegura Pensado, MartaLópez Gavín, AlexandreMorales, DulceSocias, LorenzoTrujillano, JavierVázquez, NilDot, IreneRoche Campo, FerranSancho Chinesta, SusanaCodina, JordiGarcía Prieto, EmilioPagliarani, PabloAyestarán, J. IgnacioCampi Hermoso, DavidGarcía Redruello, CarlosMenendez, RosarioRodríguez, SilviaHerraiz, AlbaMotos, AnaSerra Fortuny, MireiaÁlvarez, SergioParrilla, FranciscoBlasco Cortés, María LuisaCicuendez Ávila, RamonLorente, J. A. (José Ángel)Bofill, NeusEstella, ÁngelCarrión García, LauraSerra, LidiaEnríquez Giraudo, PedroDíaz, YolandaGalbán, CristóbalGarcía, FelipeMontejo González, Juan CarlosPablo Sánchez, Raul deVara Adrio, SabelaPujol, AndrésRubio, JorgeContreras, SofíaFarré Monjo, TeresaVal, EstelaCillóniz, CatiaClar, LuisaRuiz, Luis ValdiviaAguilera, LucianoTorres Martí, AntoniServià, LluísGumucio Sanguino, Víctor D.Marcos, PilarMartínez, MaríaLoza-Vázquez, AnaYang, HuaVengoechea, JavierPeñasco, YhivianBarbeta, EnricVilanova, JuditValdivia, Luis JorgeGallego, ElenaAmaya Villar, RosarioMartínez de la Gándara, AmaliaBeteré, BelénGómez Gonzalez, CarmenSuarez Sipmann, FernandoCampos Fernández, SandraMasclans, Joan RamonVidal, PabloMendoza, Diego dePérez Rubio, EvaGarcía Garmendia, José LuisRubio López, AlbertoMarín Corral, JudithVilà Vilardel, ClaraLeón, MiguelDíaz, Mar JuanJiménez, GabrielBigas, JuditCantón Bulnes, Maria LuisaGonzález, JessicaPérez, PurificaciónMora Aznar, MaríaDólera Moreno, CristinaBerezo García, José ÁngelJaner, Maria TeresaMenor Fernández, Eva MaríaGómez, José M.Alegre, CynthiaAñón, José M.Pérez Planelles, GloriaPozo Laderas, Juan CarlosDíaz, EmiliTamayo Lomas, LuisBadía, MarionaMoreno Cano, Sara GuadalupeMonclou, JosmanLoza Vázquez, AnaCano, IosuneÁngel, JoséMartínez Palacios, BasilisaBlancas, RafaelVallverdú, MontserratPiñol Tena, ÀngelsMármol Peis, EnriqueBustamante Munguira, JuanAguilar Cabello, MaríaHerrán Monge, RubénBodi Saera, MaríaBoado, MaríaBarberà, CarmeMarin Corral, JudithMiralbés, MarZapatero, AnaMaseda, Emilio2024-07-162024-07-162024-03-211364-8535https://hdl.handle.net/2445/214596Background Acute respiratory distress syndrome (ARDS) can be classified into sub-phenotypes according to different inflammatory/clinical status. Prognostic enrichment was achieved by grouping patients into hypoinflammatory or hyperinflammatory sub-phenotypes, even though the time of analysis may change the classification according to treatment response or disease evolution. We aimed to evaluate when patients can be clustered in more than 1 group, and how they may change the clustering of patients using data of baseline or day 3, and the prognosis of patients according to their evolution by changing or not the cluster.Methods Multicenter, observational prospective, and retrospective study of patients admitted due to ARDS related to COVID-19 infection in Spain. Patients were grouped according to a clustering mixed-type data algorithm (k-prototypes) using continuous and categorical readily available variables at baseline and day 3.Results Of 6205 patients, 3743 (60%) were included in the study. According to silhouette analysis, patients were grouped in two clusters. At baseline, 1402 (37%) patients were included in cluster 1 and 2341(63%) in cluster 2. On day 3, 1557(42%) patients were included in cluster 1 and 2086 (57%) in cluster 2. The patients included in cluster 2 were older and more frequently hypertensive and had a higher prevalence of shock, organ dysfunction, inflammatory biomarkers, and worst respiratory indexes at both time points. The 90-day mortality was higher in cluster 2 at both clustering processes (43.8% [n = 1025] versus 27.3% [n = 383] at baseline, and 49% [n = 1023] versus 20.6% [n = 321] on day 3). Four hundred and fifty-eight (33%) patients clustered in the first group were clustered in the second group on day 3. In contrast, 638 (27%) patients clustered in the second group were clustered in the first group on day 3.Conclusions During the first days, patients can be clustered into two groups and the process of clustering patients may change as they continue to evolve. This means that despite a vast majority of patients remaining in the same cluster, a minority reaching 33% of patients analyzed may be re-categorized into different clusters based on their progress. Such changes can significantly impact their prognosis.18 p.application/pdfengcc by (c) Ceccato, Adrian et al, 2024http://creativecommons.org/licenses/by/3.0/es/COVID-19Insuficiència respiratòriaCOVID-19Respiratory insufficiencyinfo:eu-repo/semantics/article2024-07-11info:eu-repo/semantics/openAccess38515193