Gamba, AndreaNicodemi, MarioSoriano i Fradera, JordiOtt, Albrecht2013-10-112013-10-1120120031-9007https://hdl.handle.net/2445/46884The formation of a hollow cellular sphere is often one of the first steps of multicellular embryonic development. In the case of Hydra, the sphere breaks its initial symmetry to form a foot-head axis. During this process a gene, ks1, is increasingly expressed in localized cell domains whose size distribution becomes scale-free at the axis-locking moment. We show that a physical model based solely on the production and exchange of ks1-promoting factors among neighboring cells robustly reproduces the scaling behavior as well as the experimentally observed spontaneous and temperature-directed symmetry breaking.5 p.application/pdfeng(c) American Physical Society, 2012HidrozousBiofísicaEmbriologiaRegeneració (Biologia)Cèl·lulesCàncerHydrozoaBiophysicsEmbryologyRegeneration (Biology)CellsCancerinfo:eu-repo/semantics/article6174802013-10-11info:eu-repo/semantics/openAccess