Hidalgo-Tenorio, CarmenVinuesa, DavidPlata, AntonioMartín-Dávila, PilarIftimie, SimonaSequera, SergioLoeches, BelénLópez Cortés, Luis EduardoFariñas, Mari CarmenFernández-Roldan, ConcepciónJavier-Martinez, RosarioMuñoz, PatriciaArenas-Miras, Maria del MarMartínez-Marcos, Francisco JavierMiró Meda, José M. (José María), 1956-Herrero, CarmenBereciartua, ElenaDe, Jesus, Samantha E.Pasquau, Juan2020-06-172020-06-172019-10-191476-0711https://hdl.handle.net/2445/166002Objectives: To analyse the effectiveness of dalbavancin (DBV) in clinical practice as consolidation therapy in patients with bloodstream infection (BSI) and/or infective endocarditis (IE) produced by gram-positive cocci (GPC), as well as its safety and pharmacoeconomic impact. Methods: A multicentre, observational and retrospective study was conducted of hospitalised patients with IE and/or BSI produced by GPC who received at least one dose of DBV. Clinical response was assessed during hospitalization, at 3 months and at 1 year. Results: Eighty-three patients with median age of 73 years were enrolled; 73.5% were male; 59.04% had BSI and 49.04% IE (44.04% prosthetic valve IE, 32.4% native IE, 23.5% pacemaker lead). The most frequently isolated microorganism was Staphylococcus aureus in BSI (49%) and coagulase-negative staphylococci in IE (44.1%). All patients with IE were clinically cured in hospital; at 12 months, there was 2.9% loss to follow-up, 8.8% mortality unrelated to IE, and 2.9% therapeutic failure rate. The percentage effectiveness of DBV to treat IE was 96.7%. The clinical cure rate for BSI was 100% during hospital stay and at 3 months; there were no recurrences or deaths during the follow-up. No patient discontinued treatment for adverse events. The saving in hospital stay was 636 days for BSI (315,424.20 ) and 557 days for IE (283,187.45 ). Conclusions: DBV is an effective consolidation antibiotic therapy in clinically stabilized patients with IE and/or BSI. It proved to be a cost-effective treatment, reducing the hospital stay, thanks to the pharmacokinetic/pharmacodynamic profile of this drug.10 p.application/pdfengcc-by (c) Hidalgo-Tenorio, Carmen et al., 2019http://creativecommons.org/licenses/by/3.0/esEndocarditisFarmacocinèticaAntibiòticsEndocarditisPharmacokineticsAntibioticsinfo:eu-repo/semantics/article6936712020-06-17info:eu-repo/semantics/openAccess31629409