Barbas Cañero, RafaelFont Bardia, Ma. MercedesProhens López, Rafael2020-05-282020-05-2820181528-7483https://hdl.handle.net/2445/162875A new anhydrous polymorph of the free base of sildenafil and two solvates (acetonitrile and propanenitrile) have been discovered and fully characterized. The new polymorph can be considered a desolvate of the acetonitrile solvate and is related to the most stable form I by morphotropism. The new polymorph can only be obtained by desolvation of the acetonitrile solvate. Thus, this study is a new example of the importance of this multicomponent family of solid forms in the discovery of new polymorphs of active pharmaceutical ingredients.27 p.application/pdfeng(c) American Chemical Society , 2018Estructura cristal·lina (Sòlids)MolèculesDissolventsLayer structure (Solids)MoleculesSolventsinfo:eu-repo/semantics/article6930552020-05-28info:eu-repo/semantics/openAccess