New polycyclic dual inhibitors of the wild type and the V27A mutant M2 channel of the influenza A virus with unexpected binding mode

Rey Carrizo, MatíasGazzarrini, SabrinaLlabrés Prat, SaloméFrigolé Vivas, MartaJuárez Jiménez, JordiFont Bardia, Ma. MercedesNaesens, LieveMoroni, AnnaLuque Garriga, F. XavierVázquez Cruz, Santiago2019-02-182019-02-182015-04-140223-5234https://hdl.handle.net/2445/128386Two new polycyclic scaffolds were synthesized and evaluated as anti-influenza A compounds. The 5-azapentacyclo[6.4.0.02,10.03,7.09,11]dodecane derivatives were only active against the wild-type M2 channel in the low-micromolar range. However, some of the 14-azaheptacyclo[8.6.1.02,5.03,11.04,9.06,17.012,16]heptadecane derivatives were dual inhibitors of the wild-type and the V27A mutant M2 channels. The antiviral activity of these molecules was confirmed by cell culture assays. Their binding mode was analysed through molecular dynamics simulations, which showed the existence of distinct binding modes in the wild type M2 channel and its V27A variant.12 p.application/pdfeng(c) Elsevier Masson SAS, 2015Química orgànicaSíntesi orgànicaVirusInfluenzavirusMedicaments antivíricsOrganic chemistryOrganic synthesisVirusesInfluenza virusesAntiviral agentsNew polycyclic dual inhibitors of the wild type and the V27A mutant M2 channel of the influenza A virus with unexpected binding modeinfo:eu-repo/semantics/article6518262019-02-18info:eu-repo/semantics/openAccess25899336