Aviñó Andrés, AnnaDellafiore, MariaGargallo Gómez, RaimundoGonzález, CarlosIribarren, Adolfo M.Montserrat, JavierEritja i Casadellà, Ramon2017-04-192018-04-132017-04-131439-4227https://hdl.handle.net/2445/109785G-quadruplex and i-motif are tetraplex structures present in telomeres and promoter regions of oncogenes. The possibility of producing nanodevices with pH-sensitive functions has triggered the interest for modified oligonucleotides with improved structural properties. We synthesized C-rich oligonucleotides carrying conformationally restricted (2'S)-2'-deoxy-2'-C-methyl-cytidine units. The effect of this modified nucleoside on the stability of intramolecular i-motifs related to vertebrate telomere was investigated by means of spectroscopic methods (UV, CD and NMR). The replacement of selected positions of the C-core by the appropriate C-modified residues induces the formation of stable intercalated tetraplexes at pHs near neutrality. The study demonstrates the possibility of enhancing the stability of i-motif by chemical modifications.7 p.application/pdfeng(c) Wiley-VCH, 2017Àcids nucleicsOligonucleòtidsG-estructuresNucleic acidsOligonucleotidesG-structuresinfo:eu-repo/semantics/article6710092017-04-19info:eu-repo/semantics/openAccess28407336